The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells

Susan M.G. Hoffman; Robert Hromas; Chris Amemiya; Harvey W. Mohrenweiser

doi:10.1016/0145-2126(95)00158-1

The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells

Susan M.G. Hoffman
, Robert Hromas
, Chris Amemiya
, Harvey W. Mohrenweiser

Producción científica: Article › revisión exhaustiva

13 Citas (Scopus)

Resumen

A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.

Idioma original	English (US)
Páginas (desde-hasta)	281-283
Número de páginas	3
Publicación	Leukemia Research
Volumen	20
N.º	3
DOI	https://doi.org/10.1016/0145-2126(95)00158-1
Estado	Published - mar 1996
Publicado de forma externa	Sí

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/0145-2126(95)00158-1

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title = "The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells",

abstract = "A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.",

keywords = "Hematopoesis, MZF-1, Telomeric degeneration",

author = "Hoffman, \{Susan M.G.\} and Robert Hromas and Chris Amemiya and Mohrenweiser, \{Harvey W.\}",

note = "Funding Information: auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract W-7405Eng-48. Author RH is a Scholar of the Leukemia Society of America and is supported by a National Institutes of Health grant HL48914.",

year = "1996",

month = mar,

doi = "10.1016/0145-2126(95)00158-1",

language = "English (US)",

volume = "20",

pages = "281--283",

journal = "Leukemia Research",

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T1 - The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells

AU - Hoffman, Susan M.G.

AU - Hromas, Robert

AU - Amemiya, Chris

AU - Mohrenweiser, Harvey W.

N1 - Funding Information: auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract W-7405Eng-48. Author RH is a Scholar of the Leukemia Society of America and is supported by a National Institutes of Health grant HL48914.

PY - 1996/3

Y1 - 1996/3

N2 - A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.

AB - A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.

KW - Hematopoesis

KW - MZF-1

KW - Telomeric degeneration

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U2 - 10.1016/0145-2126(95)00158-1

DO - 10.1016/0145-2126(95)00158-1

M3 - Article

C2 - 8637224

AN - SCOPUS:0029863179

SN - 0145-2126

VL - 20

SP - 281

EP - 283

JO - Leukemia Research

JF - Leukemia Research

IS - 3

ER -

The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells

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