The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans

Nathan P. Wiederhold; Laura K. Najvar; Annette W. Fothergill; Dora I. McCarthy; Rosie Bocanegra; Marcos Olivo; William R. Kirkpatrick; Michael P. Everson; Frederick P. Duncanson; Thomas F. Pattersona

doi:10.1128/AAC.03944-14

The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans

Nathan P. Wiederhold, Laura K. Najvar, Annette W. Fothergill, Dora I. McCarthy, Rosie Bocanegra, Marcos Olivo, William R. Kirkpatrick, Michael P. Everson, Frederick P. Duncanson, Thomas F. Pattersona

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Resumen

The in vitro and in vivo activity of the inositol acyltransferase inhibitor E1210 was evaluated against echinocandin-resistant Candida albicans. E1210 demonstrated potent in vitro activity, and in mice with invasive candidiasis caused by echinocandinresistant C. albicans, oral doses of 10 and 40 mg E1210/kg of body weight twice daily significantly improved survival and reduced fungal burden compared to those of controls and mice treated with caspofungin (10 mg/kg/day). These results demonstrate the potential use of E1210 against resistant C. albicans infections.

Idioma original	English (US)
Páginas (desde-hasta)	690-692
Número de páginas	3
Publicación	Antimicrobial agents and chemotherapy
Volumen	59
N.º	1
DOI	https://doi.org/10.1128/AAC.03944-14
Estado	Published - ene 1 2015

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Wiederhold, N. P., Najvar, L. K., Fothergill, A. W., McCarthy, D. I., Bocanegra, R., Olivo, M., Kirkpatrick, W. R., Everson, M. P., Duncanson, F. P., & Pattersona, T. F. (2015). The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans. Antimicrobial agents and chemotherapy, 59(1), 690-692. https://doi.org/10.1128/AAC.03944-14

Wiederhold, NP, Najvar, LK, Fothergill, AW, McCarthy, DI, Bocanegra, R, Olivo, M, Kirkpatrick, WR, Everson, MP, Duncanson, FP & Pattersona, TF 2015, 'The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans', Antimicrobial agents and chemotherapy, vol. 59, n.º 1, pp. 690-692. https://doi.org/10.1128/AAC.03944-14

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title = "The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans",

abstract = "The in vitro and in vivo activity of the inositol acyltransferase inhibitor E1210 was evaluated against echinocandin-resistant Candida albicans. E1210 demonstrated potent in vitro activity, and in mice with invasive candidiasis caused by echinocandinresistant C. albicans, oral doses of 10 and 40 mg E1210/kg of body weight twice daily significantly improved survival and reduced fungal burden compared to those of controls and mice treated with caspofungin (10 mg/kg/day). These results demonstrate the potential use of E1210 against resistant C. albicans infections.",

author = "Wiederhold, {Nathan P.} and Najvar, {Laura K.} and Fothergill, {Annette W.} and McCarthy, {Dora I.} and Rosie Bocanegra and Marcos Olivo and Kirkpatrick, {William R.} and Everson, {Michael P.} and Duncanson, {Frederick P.} and Pattersona, {Thomas F.}",

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doi = "10.1128/AAC.03944-14",

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AU - Wiederhold, Nathan P.

AU - Najvar, Laura K.

AU - Fothergill, Annette W.

AU - McCarthy, Dora I.

AU - Bocanegra, Rosie

AU - Olivo, Marcos

AU - Kirkpatrick, William R.

AU - Everson, Michael P.

AU - Duncanson, Frederick P.

AU - Pattersona, Thomas F.

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AB - The in vitro and in vivo activity of the inositol acyltransferase inhibitor E1210 was evaluated against echinocandin-resistant Candida albicans. E1210 demonstrated potent in vitro activity, and in mice with invasive candidiasis caused by echinocandinresistant C. albicans, oral doses of 10 and 40 mg E1210/kg of body weight twice daily significantly improved survival and reduced fungal burden compared to those of controls and mice treated with caspofungin (10 mg/kg/day). These results demonstrate the potential use of E1210 against resistant C. albicans infections.

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The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans

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