The immunology of bipolar disorder

Izabela Guimarães Barbosa, Rodrigo Machado-Vieira, Jair C. Soares, Antonio L. Teixeira

Producción científica: Articlerevisión exhaustiva

118 Citas (Scopus)


Bipolar disorder (BD) is a psychiatric condition associated with elevated frequency of clinical comorbidities and cognitive impairment. The neurobiology of BD is not completely understood. Recent evidence has implicated immune dysfunction in its physiopathology. Here, we review several data supporting the presence of immunological dysfunction in BD: (i) increased frequency of autoimmune diseases; (ii) distinct immune cell profile; (iii) release of/altered cytokines by stimulated mononuclear cells; (iv) elevated levels of circulating immune markers, and (v) inflammatory changes in the central nervous system. We also discuss the interplay between immunological dysfunction and neuroprogression in BD.

Idioma originalEnglish (US)
Páginas (desde-hasta)117-122
Número de páginas6
EstadoPublished - 2014
Publicado de forma externa

ASJC Scopus subject areas

  • Immunology
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems


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