The human transferrin gene: 5′ region contains conserved sequences which match the control elements regulated by heavy metals, glucocorticoids and acute phase reaction

Gwendolyn S. Adrian, Barry W. Korinek, Barbara H. Bowman, Yang Funmei

Resultado de la investigación: Articlerevisión exhaustiva

42 Citas (Scopus)

Resumen

Transferrin is a major plasma protein that transports iron to proliferating cells throughout the body. A clone containing the 5' region of the human transferrin gene has been isolated and characterized. A 14 kb EcoRI fragment was identified that contained the first 8 exons of the transferrin gene and 3.6 kb of its 5' flanking region. Conserved sequences identical or homologous to regulatory elements responding to heavy metals, glucocorticoid receptor and a putative acute phase reaction signal were identified in the 5' flanking region and intron 1. Also, the regulatory region of the transferrin gene contains a 14-bp sequence which closely matches sequences found in the interleukin-2 and γ-interferon genes. All three genes are expressed by T lymphocytes before proliferation. A secondary loop structure similar to that proposed for the ovotransferrin gene can be formed by sequences in the 5' untranslated region of the transferrin mRNA.

Idioma originalEnglish (US)
Páginas (desde-hasta)167-175
Número de páginas9
PublicaciónGene
Volumen49
N.º2
DOI
EstadoPublished - 1986
Publicado de forma externa

ASJC Scopus subject areas

  • Genetics

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