@article{84dbefd779ce4e97bd5005dcec9987ba,
title = "The Genetic contribution to solving the cocktail-party problem",
abstract = "Communicating in everyday situations requires solving the cocktail-party problem, or segregating the acoustic mixture into its constituent sounds and attending to those of most interest. Humans show dramatic variation in this ability, leading some to experience real-world problems irrespective of whether they meet criteria for clinical hearing loss. Here, we estimated the genetic contribution to cocktail-party listening by measuring speech-reception thresholds (SRTs) in 425 people from large families and ranging in age from 18 to 91 years. Roughly half the variance of SRTs was explained by genes (h2 = 0.567). The genetic correlation between SRTs and hearing thresholds (HTs) was medium (ρG = 0.392), suggesting that the genetic factors influencing cocktail-party listening were partially distinct from those influencing sound sensitivity. Aging and socioeconomic status also strongly influenced SRTs. These findings may represent a first step toward identifying genes for “hidden hearing loss,” or hearing problems in people with normal HTs.",
keywords = "Genetics, Health sciences, Human Genetics",
author = "Mathias, {Samuel R.} and Knowles, {Emma E.M.} and Josephine Mollon and Rodrigue, {Amanda L.} and Woolsey, {Mary K.} and Hernandez, {Alyssa M.} and Garrett, {Amy S.} and Fox, {Peter T.} and Olvera, {Rene L.} and Peralta, {Juan M.} and Satish Kumar and Goring, {Harald HH} and Ravi Duggirala and Curran, {Joanne E} and Blangero, {John C} and Glahn, {David C.}",
note = "Funding Information: This work was supported by National Institutes of Health Grant 5R01AG058464 (principal investigators D.C.G. and J.B.). We thank IGAB, NHANES, and UKBB participants for their voluntary participation. UKBB application no. 41640. Funding Information: This work was supported by National Institutes of Health Grant 5R01AG058464 (principal investigators D.C.G. and J.B.). We thank IGAB, NHANES, and UKBB participants for their voluntary participation. UKBB application no. 41640. S.R.M. designed the tasks, performed the analyses, and wrote the manuscript. D.C.G. and J.B. are joint principal investigators of the IGAB study. M.K.W. and A.M.H. collected the data. All coauthors cowrote the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
month = sep,
day = "16",
doi = "10.1016/j.isci.2022.104997",
language = "English (US)",
volume = "25",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "9",
}