The Genetic contribution to solving the cocktail-party problem

Samuel R. Mathias; Emma E.M. Knowles; Josephine Mollon; Amanda L. Rodrigue; Mary K. Woolsey; Alyssa M. Hernandez; Amy S. Garrett; Peter T. Fox; Rene L. Olvera; Juan M. Peralta; Satish Kumar; Harald HH Goring; Ravi Duggirala; Joanne E Curran; John C Blangero; David C. Glahn

doi:10.1016/j.isci.2022.104997

The Genetic contribution to solving the cocktail-party problem

Samuel R. Mathias, Emma E.M. Knowles, Josephine Mollon, Amanda L. Rodrigue, Mary K. Woolsey, Alyssa M. Hernandez, Amy S. Garrett, Peter T. Fox, Rene L. Olvera, Juan M. Peralta, Satish Kumar, Harald HH Goring, Ravi Duggirala, Joanne E Curran, John C Blangero, David C. Glahn

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Resumen

Communicating in everyday situations requires solving the cocktail-party problem, or segregating the acoustic mixture into its constituent sounds and attending to those of most interest. Humans show dramatic variation in this ability, leading some to experience real-world problems irrespective of whether they meet criteria for clinical hearing loss. Here, we estimated the genetic contribution to cocktail-party listening by measuring speech-reception thresholds (SRTs) in 425 people from large families and ranging in age from 18 to 91 years. Roughly half the variance of SRTs was explained by genes (h² = 0.567). The genetic correlation between SRTs and hearing thresholds (HTs) was medium (ρ_G = 0.392), suggesting that the genetic factors influencing cocktail-party listening were partially distinct from those influencing sound sensitivity. Aging and socioeconomic status also strongly influenced SRTs. These findings may represent a first step toward identifying genes for “hidden hearing loss,” or hearing problems in people with normal HTs.

Idioma original	English (US)
Número de artículo	104997
Publicación	iScience
Volumen	25
N.º	9
DOI	https://doi.org/10.1016/j.isci.2022.104997
Estado	Published - sept 16 2022

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Mathias, S. R., Knowles, E. E. M., Mollon, J., Rodrigue, A. L., Woolsey, M. K., Hernandez, A. M., Garrett, A. S., Fox, P. T., Olvera, R. L., Peralta, J. M., Kumar, S., Goring, H. HH., Duggirala, R., Curran, J. E., Blangero, J. C., & Glahn, D. C. (2022). The Genetic contribution to solving the cocktail-party problem. iScience, 25(9), Artículo 104997. https://doi.org/10.1016/j.isci.2022.104997

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title = "The Genetic contribution to solving the cocktail-party problem",

abstract = "Communicating in everyday situations requires solving the cocktail-party problem, or segregating the acoustic mixture into its constituent sounds and attending to those of most interest. Humans show dramatic variation in this ability, leading some to experience real-world problems irrespective of whether they meet criteria for clinical hearing loss. Here, we estimated the genetic contribution to cocktail-party listening by measuring speech-reception thresholds (SRTs) in 425 people from large families and ranging in age from 18 to 91 years. Roughly half the variance of SRTs was explained by genes (h2 = 0.567). The genetic correlation between SRTs and hearing thresholds (HTs) was medium (ρG = 0.392), suggesting that the genetic factors influencing cocktail-party listening were partially distinct from those influencing sound sensitivity. Aging and socioeconomic status also strongly influenced SRTs. These findings may represent a first step toward identifying genes for “hidden hearing loss,” or hearing problems in people with normal HTs.",

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author = "Mathias, {Samuel R.} and Knowles, {Emma E.M.} and Josephine Mollon and Rodrigue, {Amanda L.} and Woolsey, {Mary K.} and Hernandez, {Alyssa M.} and Garrett, {Amy S.} and Fox, {Peter T.} and Olvera, {Rene L.} and Peralta, {Juan M.} and Satish Kumar and Goring, {Harald HH} and Ravi Duggirala and Curran, {Joanne E} and Blangero, {John C} and Glahn, {David C.}",

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AU - Peralta, Juan M.

AU - Kumar, Satish

AU - Goring, Harald HH

AU - Duggirala, Ravi

AU - Curran, Joanne E

AU - Blangero, John C

AU - Glahn, David C.

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AB - Communicating in everyday situations requires solving the cocktail-party problem, or segregating the acoustic mixture into its constituent sounds and attending to those of most interest. Humans show dramatic variation in this ability, leading some to experience real-world problems irrespective of whether they meet criteria for clinical hearing loss. Here, we estimated the genetic contribution to cocktail-party listening by measuring speech-reception thresholds (SRTs) in 425 people from large families and ranging in age from 18 to 91 years. Roughly half the variance of SRTs was explained by genes (h2 = 0.567). The genetic correlation between SRTs and hearing thresholds (HTs) was medium (ρG = 0.392), suggesting that the genetic factors influencing cocktail-party listening were partially distinct from those influencing sound sensitivity. Aging and socioeconomic status also strongly influenced SRTs. These findings may represent a first step toward identifying genes for “hidden hearing loss,” or hearing problems in people with normal HTs.

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The Genetic contribution to solving the cocktail-party problem

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