The Endocannabinoid System and Parkinson Disease

Andrea Giuffrida, Alex Martinez

Producción científica: Chapter

8 Citas (Scopus)

Resumen

Dysregulation of the endocannabinoid system has been implicated in several neurodegenerative disorders including Parkinson disease (PD). Within the motor areas of the brain, cannabinoid and dopamine systems regulate motor function and synaptic plasticity by modulating excitatory and inhibitory neurotransmission. Alterations of this cross talk have been linked to the pathophysiology of PD and the maladaptive plasticity associated with the disabling motor complications caused by long-term use of L-DOPA. This chapter reviews the complex functional interactions between endocannabinoid and dopaminergic/glutamatergic systems in the basal ganglia, the contribution of endocannabinoid transmission dysfunction to PD and L-DOPA-induced dyskinesia, and recent preclinical studies using cannabinoid-based drugs for the pharmacotherapy of these pathologic conditions.

Idioma originalEnglish (US)
Título de la publicación alojadaThe Endocannabinoid System
Subtítulo de la publicación alojadaGenetics, Biochemistry, Brain Disorders, and Therapy
EditorialElsevier Inc.
Páginas63-81
Número de páginas19
ISBN (versión digital)9780128096673
ISBN (versión impresa)9780128096666
DOI
EstadoPublished - may 16 2017

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences

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