The Emerging Threat of Antifungal Resistance in Transplant Infectious Diseases

Ilan S. Schwartz, Thomas F Patterson

Resultado de la investigación: Review articlerevisión exhaustiva

28 Citas (Scopus)


Purpose of Review: The global emergence of antifungal resistance among Candida spp. and Aspergillus spp. will disproportionately affect transplantation recipients, who are prone to invasive fungal disease. Recent Findings: Invasive candidiasis is increasingly caused by non-albicans Candida species with reduced susceptibility to first-line antifungals. Echinocandin resistance in Candida glabrata is increasing in some settings. Candida auris has rapidly emerged as a global concern due to multidrug resistance and efficient nosocomial spread in healthcare settings. Azole-resistant Aspergillus fumigatus is already an important concern in some European countries and is increasingly reported elsewhere, possibly driven by agricultural use of triazole fungicides. Summary: Antifungal resistance is anticipated to expand among these and other common fungal pathogens. Culture-independent detection methods will become more important for rapid diagnosis and to guide empiric therapy. Antifungal stewardship is of critical importance to conserve our limited antifungal armamentarium for transplantation recipients and other vulnerable patients.

Idioma originalEnglish (US)
Número de artículo2
PublicaciónCurrent Infectious Disease Reports
EstadoPublished - mar 1 2018

ASJC Scopus subject areas

  • Infectious Diseases


Profundice en los temas de investigación de 'The Emerging Threat of Antifungal Resistance in Transplant Infectious Diseases'. En conjunto forman una huella única.

Citar esto