The effect of vasopressin on portal hypertension following hepatectomy

K. R. Sirinek, N. R. Thomford

Resultado de la investigación: Articlerevisión exhaustiva

13 Citas (Scopus)


Portal hypertension with splanchnic sequestration of blood is a serious physiologic consequence of major hepatic resection. In this study, the pharmacologic control of portal hypertension following hepatectomy was evaluated in dogs. The marked increase in portal vein pressure associated with major hepatic resection was confirmed in control experiments. Administration of vasopressin in advance of hepatectomy prevented portal hypertension following hepatectomy but caused a reduction in cardiac output. However, when some vasopressin treated dogs were given isoproterenol at the time of hepatectomy, the vasopressin induced reduction in cardiac output was corrected. The addition of isoproterenol did not interfere with the prevention of portal hypertension by vasopressin. Results of these studies suggest that the administration of vasopressin alone or in combination with isoproterenol to selected patients undergoing major hepatic resection may prevent the life threatening sequestration of blood in the splanchnic vascular bed.

Idioma originalEnglish (US)
Páginas (desde-hasta)573-577
Número de páginas5
PublicaciónSurgery Gynecology and Obstetrics
EstadoPublished - dic 1 1974
Publicado de forma externa

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology


Profundice en los temas de investigación de 'The effect of vasopressin on portal hypertension following hepatectomy'. En conjunto forman una huella única.

Citar esto