TY - JOUR
T1 - The effect of propranolol on blood pressure and central MOPEG concentration in the conscious spontaneously hypertensive rat
AU - Kent Keeton, T.
AU - Hall, James S.
PY - 1986/6/17
Y1 - 1986/6/17
N2 - The total concentration of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyl glycol (MOPEG) and propranolol concentration was measured in the medulla, pons, hypothalamus and thoracic spinal cord of conscious spontaneously hypertensive rats during the development of the antihypertensive effect of a single dose of d,1-propranolol (10 mg/kg s.c.). Propranolol significantly increased MOPEG concentration by 21% in the thoracic spinal cord (2 h) and 16% in the hypothalamus (4 h), but no consistent pattern of change in regional MOPEG concentration was found in relation to the time course of the antihypertensive effect of propranolol.
AB - The total concentration of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyl glycol (MOPEG) and propranolol concentration was measured in the medulla, pons, hypothalamus and thoracic spinal cord of conscious spontaneously hypertensive rats during the development of the antihypertensive effect of a single dose of d,1-propranolol (10 mg/kg s.c.). Propranolol significantly increased MOPEG concentration by 21% in the thoracic spinal cord (2 h) and 16% in the hypothalamus (4 h), but no consistent pattern of change in regional MOPEG concentration was found in relation to the time course of the antihypertensive effect of propranolol.
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U2 - 10.1016/0014-2999(86)90040-3
DO - 10.1016/0014-2999(86)90040-3
M3 - Article
C2 - 3743639
AN - SCOPUS:0022504444
SN - 0014-2999
VL - 125
SP - 293
EP - 296
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -