The effect of aging and dietary restriction on DNA repair

Nataya Weraarchakul; Randy Strong; W. Gibson Wood; Arlan G Richardson

doi:10.1016/0014-4827(89)90193-6

The effect of aging and dietary restriction on DNA repair

Nataya Weraarchakul, Randy Strong, W. Gibson Wood, Arlan G Richardson

Producción científica: Article › revisión exhaustiva

83 Citas (Scopus)

Resumen

DNA repair was studied as a function of age in cells isolated from both the liver and the kidney of male Fischer F344 rats. DNA repair was measured by quantifying unscheduled DNA synthesis induced by UV irradiation. Unscheduled DNA synthesis decreased approximately 50% between the ages of 5 and 30 months in both hepatocytes and kidney cells. The age-related decline in unscheduled DNA synthesis in cells isolated from the liver and kidney was compared in rats fed ad libitum and rats fed a calorie-restricted diet; calorie restriction has been shown to increase the survival of rodents. The level of unscheduled DNA synthesis was significantly higher in hepatocytes and kidney cells isolated from the rats fed the restricted diet. Thus, calorie restriction appears to retard the age-related decline in DNA repair.

Idioma original	English (US)
Páginas (desde-hasta)	197-204
Número de páginas	8
Publicación	Experimental Cell Research
Volumen	181
N.º	1
DOI	https://doi.org/10.1016/0014-4827(89)90193-6
Estado	Published - mar 1989
Publicado de forma externa	Sí

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Cell Biology

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title = "The effect of aging and dietary restriction on DNA repair",

abstract = "DNA repair was studied as a function of age in cells isolated from both the liver and the kidney of male Fischer F344 rats. DNA repair was measured by quantifying unscheduled DNA synthesis induced by UV irradiation. Unscheduled DNA synthesis decreased approximately 50% between the ages of 5 and 30 months in both hepatocytes and kidney cells. The age-related decline in unscheduled DNA synthesis in cells isolated from the liver and kidney was compared in rats fed ad libitum and rats fed a calorie-restricted diet; calorie restriction has been shown to increase the survival of rodents. The level of unscheduled DNA synthesis was significantly higher in hepatocytes and kidney cells isolated from the rats fed the restricted diet. Thus, calorie restriction appears to retard the age-related decline in DNA repair.",

author = "Nataya Weraarchakul and Randy Strong and Wood, {W. Gibson} and Richardson, {Arlan G}",

note = "Funding Information: This research was supported by NIH Grant AG 01548.",

year = "1989",

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T1 - The effect of aging and dietary restriction on DNA repair

AU - Weraarchakul, Nataya

AU - Strong, Randy

AU - Wood, W. Gibson

AU - Richardson, Arlan G

N1 - Funding Information: This research was supported by NIH Grant AG 01548.

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N2 - DNA repair was studied as a function of age in cells isolated from both the liver and the kidney of male Fischer F344 rats. DNA repair was measured by quantifying unscheduled DNA synthesis induced by UV irradiation. Unscheduled DNA synthesis decreased approximately 50% between the ages of 5 and 30 months in both hepatocytes and kidney cells. The age-related decline in unscheduled DNA synthesis in cells isolated from the liver and kidney was compared in rats fed ad libitum and rats fed a calorie-restricted diet; calorie restriction has been shown to increase the survival of rodents. The level of unscheduled DNA synthesis was significantly higher in hepatocytes and kidney cells isolated from the rats fed the restricted diet. Thus, calorie restriction appears to retard the age-related decline in DNA repair.

AB - DNA repair was studied as a function of age in cells isolated from both the liver and the kidney of male Fischer F344 rats. DNA repair was measured by quantifying unscheduled DNA synthesis induced by UV irradiation. Unscheduled DNA synthesis decreased approximately 50% between the ages of 5 and 30 months in both hepatocytes and kidney cells. The age-related decline in unscheduled DNA synthesis in cells isolated from the liver and kidney was compared in rats fed ad libitum and rats fed a calorie-restricted diet; calorie restriction has been shown to increase the survival of rodents. The level of unscheduled DNA synthesis was significantly higher in hepatocytes and kidney cells isolated from the rats fed the restricted diet. Thus, calorie restriction appears to retard the age-related decline in DNA repair.

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The effect of aging and dietary restriction on DNA repair

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