The Diverse Roles of RNA-Binding Proteins in Glioma Development

Mitzli X. Velasco, Adam Kosti, Luiz O.F. Penalva, Greco Hernández

Producción científica: Chapter

23 Citas (Scopus)

Resumen

Post-transcriptional regulation of gene expression is fundamental for all forms of life, as it critically contributes to the composition and quantity of a cell’s proteome. These processes encompass splicing, polyadenylation, mRNA decay, mRNA editing and modification and translation and are modulated by a variety of RNA-binding proteins (RBPs). Alterations affecting RBP expression and activity contribute to the development of different types of cancer. In this chapter, we discuss current research shedding light on the role of different RBPs in gliomas. These studies place RBPs as modulators of critical signaling pathways, establish their relevance as prognostic markers and open doors for new therapeutic strategies.

Idioma originalEnglish (US)
Título de la publicación alojadaAdvances in Experimental Medicine and Biology
EditorialSpringer New York LLC
Páginas29-39
Número de páginas11
DOI
EstadoPublished - 2019

Serie de la publicación

NombreAdvances in Experimental Medicine and Biology
Volumen1157
ISSN (versión impresa)0065-2598
ISSN (versión digital)2214-8019

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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