The default mode network and related right hemisphere structures may be the key substrates of dementia

Donald R. Royall, Raymond F. Palmer, Eric D. Vidoni, Robyn A. Honea, Jeffrey M. Burns

Producción científica: Articlerevisión exhaustiva

37 Citas (Scopus)

Resumen

We have employed structural equation models to explicitly distinguish dementia-relevant variance in cognitive task performance (i.e., δ) from the variance that is unrelated to a dementing process (i.e., g'). Together g' and d comprise Spearman's "g". Although d represents only a minor fraction of the total variance in cognitive task performance, it is more strongly associated with dementia severity than is g'. In this analysis, we replicate δ in a new dataspace, the University of Kansas Brain Aging Project, and associate it specifically with regional grey matter atrophy by voxel-based morphometry of magnetic resonance imaging data. The latent variable d localizes to elements of the default mode network and related structures in the R hemisphere.

Idioma originalEnglish (US)
Páginas (desde-hasta)467-478
Número de páginas12
PublicaciónJournal of Alzheimer's Disease
Volumen32
N.º2
DOI
EstadoPublished - 2012

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Clinical Psychology
  • General Neuroscience

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