The complex world of kidney microRNAs

Balakuntalam S. Kasinath; Denis Feliers

doi:10.1038/ki.2011.165

The complex world of kidney microRNAs

Balakuntalam S. Kasinath, Denis Feliers

Department of Medicine

Resultado de la investigación: Comment/debate › revisión exhaustiva

30 Citas (Scopus)

Resumen

MicroRNAs are short noncoding RNAs that usually reduce translation of messenger RNAs. Changes in microRNA-192 (miR-192) are reported in states of renal fibrosis. New evidence supports a role for miR-192 and its target miR-200b/c in transforming growth factor-Β1 regulation of its own expression and that of collagens in mesangial cells, with a possible role in diabetic nephropathy. As there is controversy on the role of these microRNAs in diabetic nephropathy, more work is needed.

Idioma original	English (US)
Páginas (desde-hasta)	334-337
Número de páginas	4
Publicación	Kidney international
Volumen	80
N.º	4
DOI	https://doi.org/10.1038/ki.2011.165
Estado	Published - ago 2 2011

ASJC Scopus subject areas

Nephrology

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abstract = "MicroRNAs are short noncoding RNAs that usually reduce translation of messenger RNAs. Changes in microRNA-192 (miR-192) are reported in states of renal fibrosis. New evidence supports a role for miR-192 and its target miR-200b/c in transforming growth factor-Β1 regulation of its own expression and that of collagens in mesangial cells, with a possible role in diabetic nephropathy. As there is controversy on the role of these microRNAs in diabetic nephropathy, more work is needed.",

author = "Kasinath, {Balakuntalam S.} and Denis Feliers",

note = "Funding Information: This work was supported by the National Institutes of Health (DK077295 and RC2 AG036613) and the Veterans Affairs Medical Research Service.",

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AU - Feliers, Denis

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PY - 2011/8/2

Y1 - 2011/8/2

N2 - MicroRNAs are short noncoding RNAs that usually reduce translation of messenger RNAs. Changes in microRNA-192 (miR-192) are reported in states of renal fibrosis. New evidence supports a role for miR-192 and its target miR-200b/c in transforming growth factor-Β1 regulation of its own expression and that of collagens in mesangial cells, with a possible role in diabetic nephropathy. As there is controversy on the role of these microRNAs in diabetic nephropathy, more work is needed.

AB - MicroRNAs are short noncoding RNAs that usually reduce translation of messenger RNAs. Changes in microRNA-192 (miR-192) are reported in states of renal fibrosis. New evidence supports a role for miR-192 and its target miR-200b/c in transforming growth factor-Β1 regulation of its own expression and that of collagens in mesangial cells, with a possible role in diabetic nephropathy. As there is controversy on the role of these microRNAs in diabetic nephropathy, more work is needed.

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The complex world of kidney microRNAs

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