The changing landscape of gene editing tool delivery in neurological disorders

Yu Ju Chen; Abhik Paul; Michael Gregory Collins; Hye Young Lee

doi:10.1016/j.cobme.2023.100509

The changing landscape of gene editing tool delivery in neurological disorders

Yu Ju Chen, Abhik Paul, Michael Gregory Collins, Hye Young Lee

Department of Cellular & Integrative Physiology

Producción científica: Review article › revisión exhaustiva

2 Citas (Scopus)

Resumen

The delivery of gene editing tools has made significant advancements in recent years. This being said, the brain remains a challenging organ for the safe and efficient delivery of gene editing tools. As nonviral delivery vehicles have shown promise with their safety profiles and biocompatibility, there have been efforts to test nonviral delivery vehicles for gene editing tools in the brain. Here, we review recent advancements in gene editing tool development and discuss how they were tested using nonviral delivery vehicles, with a specific focus on brain applications.

Idioma original	English (US)
Número de artículo	100509
Publicación	Current Opinion in Biomedical Engineering
Volumen	28
DOI	https://doi.org/10.1016/j.cobme.2023.100509
Estado	Published - dic 2023

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

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title = "The changing landscape of gene editing tool delivery in neurological disorders",

abstract = "The delivery of gene editing tools has made significant advancements in recent years. This being said, the brain remains a challenging organ for the safe and efficient delivery of gene editing tools. As nonviral delivery vehicles have shown promise with their safety profiles and biocompatibility, there have been efforts to test nonviral delivery vehicles for gene editing tools in the brain. Here, we review recent advancements in gene editing tool development and discuss how they were tested using nonviral delivery vehicles, with a specific focus on brain applications.",

keywords = "Brain disorders, CRISPR/Cas9, Gene editing, Nnonviral vector",

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AU - Lee, Hye Young

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KW - CRISPR/Cas9

KW - Gene editing

KW - Nnonviral vector

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The changing landscape of gene editing tool delivery in neurological disorders

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