The application of positron emission tomography to the study of panic disorder

E. M. Reiman, M. E. Raichle, E. Robins, F. K. Butler, P. Herscovitch, P. Fox, J. Perlmutter

Producción científica: Articlerevisión exhaustiva

251 Citas (Scopus)

Resumen

Positron emission tomography was used to study eight patients with panic disorder who were vulnerable to lactate-induced panic, eight patients with panic disorder who were not vulnerable to lactate-induced panic, and 25 normal control subjects. Patients who were vulnerable to lactate-induced panic had several abnormalities in the resting, nonpanic state: an abnormal hemispheric asymmetry of parahippocampal blood flow, blood volume, and oxygen metabolism; abnormally high whole brain metabolism; and abnormal susceptibility to episodic hyperventilation. A hypothetical model for the neurobiology of panic disorder, involving the abnormal parahippocampal region and its afferent and efferent connections is proposed.

Idioma originalEnglish (US)
Páginas (desde-hasta)469-477
Número de páginas9
PublicaciónAmerican Journal of Psychiatry
Volumen143
N.º4
DOI
EstadoPublished - 1986
Publicado de forma externa

ASJC Scopus subject areas

  • Psychiatry and Mental health

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