@article{53b0fb4ded7d42f9af21ef00fbe40798,
title = "T2Candida provides rapid and accurate species identification in pediatric cases of Candidemia",
abstract = "Objectives: The goal of this study is to assess the ability of the T2Candida platform (T2 Biosystems, Lexington, MA) to accurately identify Candida species from pediatric blood specimens with low volumes. Methods: Whole blood from 15 children with candidemia was collected immediately following blood culture draw. The amount of blood required by the system was reduced by pipetting whole blood directly onto the T2Candida cartridge. Specimens were subsequently run on the T2Dx Instrument (T2 Biosystems). Results: The T2Candida panel provided the appropriate result for each specimen compared with blood culture-based species identification and correctly identified 15 positive and nine negative results in 3 to 5 hours. While the time to species identification for blood culture was not reported, the T2Candida results include species data. Conclusions: T2Candida can be used to efficiently diagnose or rule out candidemia using low-volume blood specimens from pediatric patients. This could result in improved time to appropriate antifungal therapy or reduction in unnecessary empirical antifungal therapy.",
keywords = "Candida, Direct detection, T2Candida",
author = "Hamula, {Camille L.} and Kenneth Hughes and Fisher, {Brian T.} and Zaoutis, {Theoklis E.} and Singh, {Ila R.} and Aristea Velegraki",
note = "Funding Information: Corresponding author: Camille Hamula, Rm 9-52A Icahn Bldg, 1425 Madison Ave, New York, NY 10029; camille.hamula@mssm1.edu. Acknowledgments: We thank A. Pangalis and A. Stathi, PhD, Microbiology Laboratory, “Aghia Sophia” Children{\textquoteright}s Hospital, Athens, Greece; Rahul Dhanda and Mike Min from T2 Biosystems for their invaluable input; and Angela Rendo, Lillian Accardo, and Thip Nguyen from the Mount Sinai Hospital Clinical Microbiology Laboratory. Disclaimers: A.V. has received unrestricted research grants from Pfizer, Astellas, and MSD. B.F. receives research funding from Pfizer and Merck. Funding Information: Acknowledgments: We thank A. Pangalis and A. Stathi, PhD, Microbiology Laboratory, “Aghia Sophia” Children's Hospital, Athens, Greece; Rahul Dhanda and Mike Min from T2 Biosystems for their invaluable input; and Angela Rendo, Lillian Accardo, and Thip Nguyen from the Mount Sinai Hospital Clinical Microbiology Laboratory. Publisher Copyright: {\textcopyright} American Society for Clinical Pathology, 2016. All rights reserved.",
year = "2016",
month = jun,
day = "1",
doi = "10.1093/ajcp/aqw063",
language = "English (US)",
volume = "145",
pages = "858--861",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "6",
}