T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes

Aline Silva de Miranda; Rodrigo Novaes Ferreira; Érica Leandro Marciano Vieira; Larissa Katharina Sabino Abreu; Fátima Brant; Luciene Bruno Vieira; Fabíola Mara Ribeiro; Fabiana Simão Machado; Milene Alvarenga Rachid; Antônio Lúcio Teixeira

doi:10.1016/j.jneuroim.2019.02.002

T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes

Aline Silva de Miranda, Rodrigo Novaes Ferreira, Érica Leandro Marciano Vieira, Larissa Katharina Sabino Abreu, Fátima Brant, Luciene Bruno Vieira, Fabíola Mara Ribeiro, Fabiana Simão Machado, Milene Alvarenga Rachid, Antônio Lúcio Teixeira

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1 Cita (Scopus)

Resumen

Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade of glutamate NMDA receptors by its noncompetitive antagonist MK801 modulates cytokine and neurotrophic factors expression preventing cognitive and depressive-like behavior in experimental CM. Herein, we aim to investigate the role of T lymphocytes in later outcomes in CM, and whether the protective role of MK801 is associated with T lymphocytes response.

Idioma original	English (US)
Páginas (desde-hasta)	5-11
Número de páginas	7
Publicación	Journal of Neuroimmunology
Volumen	330
DOI	https://doi.org/10.1016/j.jneuroim.2019.02.002
Estado	Published - may 15 2019
Publicado de forma externa	Sí

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2019.02.002

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de Miranda, A. S., Ferreira, R. N., Vieira, É. L. M., Abreu, L. K. S., Brant, F., Vieira, L. B., Ribeiro, F. M., Machado, F. S., Rachid, M. A., & Teixeira, A. L. (2019). T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes. Journal of Neuroimmunology, 330, 5-11. https://doi.org/10.1016/j.jneuroim.2019.02.002

T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes. / de Miranda, Aline Silva; Ferreira, Rodrigo Novaes; Vieira, Érica Leandro Marciano et al.
En: Journal of Neuroimmunology, Vol. 330, 15.05.2019, p. 5-11.

Producción científica: Article › revisión exhaustiva

de Miranda, AS, Ferreira, RN, Vieira, ÉLM, Abreu, LKS, Brant, F, Vieira, LB, Ribeiro, FM, Machado, FS, Rachid, MA & Teixeira, AL 2019, 'T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes', Journal of Neuroimmunology, vol. 330, pp. 5-11. https://doi.org/10.1016/j.jneuroim.2019.02.002

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title = "T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes",

abstract = "Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade of glutamate NMDA receptors by its noncompetitive antagonist MK801 modulates cytokine and neurotrophic factors expression preventing cognitive and depressive-like behavior in experimental CM. Herein, we aim to investigate the role of T lymphocytes in later outcomes in CM, and whether the protective role of MK801 is associated with T lymphocytes response.",

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AU - Ferreira, Rodrigo Novaes

AU - Vieira, Érica Leandro Marciano

AU - Abreu, Larissa Katharina Sabino

AU - Brant, Fátima

AU - Vieira, Luciene Bruno

AU - Ribeiro, Fabíola Mara

AU - Machado, Fabiana Simão

AU - Rachid, Milene Alvarenga

AU - Teixeira, Antônio Lúcio

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AB - Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade of glutamate NMDA receptors by its noncompetitive antagonist MK801 modulates cytokine and neurotrophic factors expression preventing cognitive and depressive-like behavior in experimental CM. Herein, we aim to investigate the role of T lymphocytes in later outcomes in CM, and whether the protective role of MK801 is associated with T lymphocytes response.

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KW - Chloroquine

KW - Glutamate

KW - MK801

KW - Malaria

KW - T lymphocytes

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ER -

T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes

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ASJC Scopus subject areas

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