Synthetic oleanane triterpenoids: Magic bullets or not?

Hanna E. Abboud

Resultado de la investigación: Comment/debaterevisión exhaustiva

13 Citas (Scopus)


A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.

Idioma originalEnglish (US)
Páginas (desde-hasta)785-787
Número de páginas3
PublicaciónKidney international
EstadoPublished - may 2013

ASJC Scopus subject areas

  • Nephrology


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