Synthesis of Pyridodiindoles with Anticancer Activity by a Three-Component Cascade Condensation

Zhong Zhu Chen, Shi Qiang Li, Ya Jun Zhang, Dian Yong Tang, Jiang Ping Meng, Jie Lei, Hong Yu Li, Zhi Gang Xu

Producción científica: Articlerevisión exhaustiva

20 Citas (Scopus)

Resumen

A novel three-component cascade reaction was discovered and developed to synthesize pyridodiindoles with the assistance of microwave irradiation. A collection of pyridodiindoles was prepared by means of the mild reaction and simple operation procedure, which could be applicable to a broad scope of functional aldehydes. Screening demonstrated that compound 5g exhibited a good potency in HCT116 cell lines, and this work validated the feasibility of this novel reaction for generating promising bioactive compounds.

Idioma originalEnglish (US)
Páginas (desde-hasta)7811-7815
Número de páginas5
PublicaciónOrganic Letters
Volumen20
N.º24
DOI
EstadoPublished - dic 21 2018
Publicado de forma externa

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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