Synthesis and distribution of CARDS toxin during mycoplasma pneumoniae infection in a murine model

T. R. Kannan, Jacqueline J. Coalson, Marianna Cagle, Oxana Musatovova, R. Doug Hardy, Joel B. Baseman

Producción científica: Articlerevisión exhaustiva

33 Citas (Scopus)

Resumen

Mice were infected with Mycoplasma pneumoniae and monitored for the synthesis and distribution of the unique adenosine diphosphate-ribosylating and vacuolating Community Acquired Respiratory Distress Syndrome (CARDS) toxin in bronchiolar lavage fluid (BALF) and lung. We noted direct relationships between the concentration of CARDS toxin and numbers of mycoplasma genomes in BALF and the degree of histologic pulmonary inflammation. Immunostaining of lungs revealed extensive colonization by mycoplasmas, including the detection of CARDS toxin in the corresponding inflamed airways. Lung lesion scores were higher during the early stages of infection, decreased gradually by day 14 postinfection, and reached substantially lower values at day 35. Infected mouse immunoglobulin (Ig) M and IgG titers were positive for CARDS toxin as well as for the major adhesin P1 of M. pneumoniae. These data reinforce the proposed pathogenic role of CARDS toxin in M. pneumoniae-mediated pathologies.

Idioma originalEnglish (US)
Páginas (desde-hasta)1596-1604
Número de páginas9
PublicaciónJournal of Infectious Diseases
Volumen204
N.º10
DOI
EstadoPublished - nov 15 2011

ASJC Scopus subject areas

  • General Medicine

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