Synthesis and Biological Evaluations of Electrophilic Steroids Inspired by the Taccalonolides

Nicholas A. Clanton, Shayne D. Hastings, Griffin B. Foultz, Julie A. Contreras, Samantha S. Yee, Hadi D. Arman, April L. Risinger, Doug E. Frantz

Producción científica: Articlerevisión exhaustiva

1 Cita (Scopus)

Resumen

Natural products have served as inspirational scaffolds for the design and synthesis of novel antineoplastic agents. Here we present our preliminary efforts on the synthesis and biological evaluation of a new class of electrophilic steroids inspired by the naturally occurring taccalonolides. We demonstrate that these simplified analogs exhibit highly persistent antiproliferative properties similar to the taccalonolides and retain activity against resistant cancer cell lines that warrants further preclinical development.

Idioma originalEnglish (US)
Páginas (desde-hasta)2534-2543
Número de páginas10
PublicaciónACS Medicinal Chemistry Letters
Volumen11
N.º12
DOI
EstadoPublished - dic 10 2020

ASJC Scopus subject areas

  • Drug Discovery
  • Biochemistry
  • Organic Chemistry

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