Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels

Ehsan Shirzaei Sani, Ahmad Kheirkhah, Devyesh Rana, Zhongmou Sun, William Foulsham, Amir Sheikhi, Ali Khademhosseini, Reza Dana, Nasim Annabi

Producción científica: Articlerevisión exhaustiva

248 Citas (Scopus)

Resumen

Corneal injuries are common causes of visual impairment worldwide. Accordingly, there is an unmet need for transparent biomaterials that have high adhesion, cohesion, and regenerative properties. Herein, we engineer a highly biocompatible and transparent bioadhesive for corneal reconstruction using a visible light cross-linkable, naturally derived polymer, GelCORE (gel for corneal regeneration). The physical properties of GelCORE could be finely tuned by changing prepolymer concentration and photocrosslinking time. GelCORE revealed higher tissue adhesion compared to commercial adhesives. Furthermore, in situ photopolymerization of GelCORE facilitated easy delivery to the cornea, allowing for bioadhesive curing precisely according to the required geometry of the defect. In vivo experiments, using a rabbit stromal defect model, showed that bioadhesive could effectively seal corneal defects and induce stromal regeneration and re-epithelialization. Overall, GelCORE has many advantages including low cost and ease of production and use. This makes GelCORE a promising bioadhesive for corneal repair.

Idioma originalEnglish (US)
Número de artículoeaav1281
PublicaciónScience Advances
Volumen5
N.º3
DOI
EstadoPublished - 2019
Publicado de forma externa

ASJC Scopus subject areas

  • General

Huella

Profundice en los temas de investigación de 'Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels'. En conjunto forman una huella única.

Citar esto