Sugar, Sex, and TGF-β in Diabetic Nephropathy

Maggie K. Diamond-Stanic; Young H. You; Kumar Sharma

doi:10.1016/j.semnephrol.2012.04.005

Sugar, Sex, and TGF-β in Diabetic Nephropathy

Maggie K. Diamond-Stanic
, Young H. You
, Kumar Sharma

Producción científica: Article › revisión exhaustiva

32 Citas (Scopus)

Resumen

TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

Idioma original	English (US)
Páginas (desde-hasta)	261-268
Número de páginas	8
Publicación	Seminars in nephrology
Volumen	32
N.º	3
DOI	https://doi.org/10.1016/j.semnephrol.2012.04.005
Estado	Published - may 2012
Publicado de forma externa	Sí

ASJC Scopus subject areas

Nephrology

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10.1016/j.semnephrol.2012.04.005

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title = "Sugar, Sex, and TGF-β in Diabetic Nephropathy",

abstract = "TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.",

keywords = "Diabetes, Kidney, Sex difference",

author = "Diamond-Stanic, \{Maggie K.\} and You, \{Young H.\} and Kumar Sharma",

note = "Funding Information: Financial support: Supported in part by National Institutes of Health ( R01 DK 053867 and U01 DK 060995 ), and a VA Merit Award. ",

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AU - Diamond-Stanic, Maggie K.

AU - You, Young H.

AU - Sharma, Kumar

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N2 - TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

AB - TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

KW - Diabetes

KW - Kidney

KW - Sex difference

UR - https://www.scopus.com/pages/publications/84864131121

UR - https://www.scopus.com/pages/publications/84864131121#tab=citedBy

U2 - 10.1016/j.semnephrol.2012.04.005

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JF - Seminars in nephrology

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ER -

Sugar, Sex, and TGF-β in Diabetic Nephropathy

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