Successful treatment of neutropenia in the hyper-immunoglobulin M syndrome with granulocyte colony-stimulating factor

W. C. Wang, J. Cordoba, A. J. Infante, M. E. Conley

Resultado de la investigación: Articlerevisión exhaustiva

36 Citas (Scopus)

Resumen

Patient: A young boy with hyper-immunoglobulin M (IgM) syndrome had recurrent severe infections, failure to thrive, and chronic neutropenia for 2 years despite treatment with i.v. gammaglobulin (IVIG). Methods and Results: With the addition of granulocyte colony-stimulating factor (G-CSF: Filgrastim, Amgen, Inc., Thousand Oaks, CA), increased doses of IVIG, and prophylactic trimethoprim-sulfamethoxazole, his absolute neutrophil count increased from 0.64 x 109/L to 3.36 x 109/L, and he has been free of significant infection for the past 22 months. Conclusions: The use of G-CSF merits consideration in patients with hyper-IgM syndrome and severe neutropenia.

Idioma originalEnglish (US)
Páginas (desde-hasta)160-163
Número de páginas4
PublicaciónAmerican Journal of Pediatric Hematology/Oncology
Volumen16
N.º2
EstadoPublished - ene. 1 1994
Publicado de forma externa

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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