Patient: A young boy with hyper-immunoglobulin M (IgM) syndrome had recurrent severe infections, failure to thrive, and chronic neutropenia for 2 years despite treatment with i.v. gammaglobulin (IVIG). Methods and Results: With the addition of granulocyte colony-stimulating factor (G-CSF: Filgrastim, Amgen, Inc., Thousand Oaks, CA), increased doses of IVIG, and prophylactic trimethoprim-sulfamethoxazole, his absolute neutrophil count increased from 0.64 x 109/L to 3.36 x 109/L, and he has been free of significant infection for the past 22 months. Conclusions: The use of G-CSF merits consideration in patients with hyper-IgM syndrome and severe neutropenia.
|Idioma original||English (US)|
|Número de páginas||4|
|Publicación||American Journal of Pediatric Hematology/Oncology|
|Estado||Published - ene. 1 1994|
|Publicado de forma externa||Sí|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health