Structure and distribution of a broadly expressed atypical sodium channel

Armen N. Akopian; Veronika Souslova; Lucia Sivilotti; John N. Wood

doi:10.1016/S0014-5793(96)01389-0

Structure and distribution of a broadly expressed atypical sodium channel

Armen N. Akopian, Veronika Souslova, Lucia Sivilotti, John N. Wood

Producción científica: Article › revisión exhaustiva

63 Citas (Scopus)

Resumen

A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na⁺ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.

Idioma original	English (US)
Páginas (desde-hasta)	183-187
Número de páginas	5
Publicación	FEBS Letters
Volumen	400
N.º	2
DOI	https://doi.org/10.1016/S0014-5793(96)01389-0
Estado	Published - ene 3 1997
Publicado de forma externa	Sí

ASJC Scopus subject areas

Genetics
Molecular Biology
Biophysics
Structural Biology
Biochemistry
Cell Biology

Acceder al documento

10.1016/S0014-5793(96)01389-0

Otros archivos y enlaces

Citar esto

@article{c34de9d509e8462b8e51ab9649d4188f,

title = "Structure and distribution of a broadly expressed atypical sodium channel",

abstract = "A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na+ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.",

keywords = "Dorsal root ganglion, Voltage-gated sodium channel, cDNA cloning",

author = "Akopian, {Armen N.} and Veronika Souslova and Lucia Sivilotti and Wood, {John N.}",

note = "Funding Information: We thank the Royal Society, The Wellcome Trust, and the MRC for support. ",

year = "1997",

month = jan,

day = "3",

doi = "10.1016/S0014-5793(96)01389-0",

language = "English (US)",

volume = "400",

pages = "183--187",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Structure and distribution of a broadly expressed atypical sodium channel

AU - Akopian, Armen N.

AU - Souslova, Veronika

AU - Sivilotti, Lucia

AU - Wood, John N.

N1 - Funding Information: We thank the Royal Society, The Wellcome Trust, and the MRC for support.

PY - 1997/1/3

Y1 - 1997/1/3

N2 - A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na+ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.

AB - A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na+ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.

KW - Dorsal root ganglion

KW - Voltage-gated sodium channel

KW - cDNA cloning

UR - http://www.scopus.com/inward/record.url?scp=0031022041&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031022041&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(96)01389-0

DO - 10.1016/S0014-5793(96)01389-0

M3 - Article

C2 - 9001394

AN - SCOPUS:0031022041

SN - 0014-5793

VL - 400

SP - 183

EP - 187

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Structure and distribution of a broadly expressed atypical sodium channel

Resumen

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto