Structural brain changes in bipolar disorder using deformation field morphometry

Jair C. Soares, Peter Kochunov, E. Serap Monkul, Mark A. Nicoletti, Paolo Brambilla, Roberto B. Sassi, Alan G. Mallinger, Ellen Frank, David J. Kupfer, Jack Lancaster, Peter Fox

Producción científica: Articlerevisión exhaustiva

41 Citas (Scopus)


The objective of this study was to investigate anatomical brain abnormalities in adult bipolar patients using a deformation field morphometry technique. Our sample consisted of 32 right-handed bipolar I patients (men/women=16/16) and 32 right-handed, age and gender matched healthy controls. Deformation field morphometry analysis was performed on three-dimensional spoiled gradient recalled acquisition images. We found gender-specific structural differences between bipolar patients and healthy individuals. Bipolar men had significantly larger lateral ventricles (especially pronounced in the left hemisphere) and smaller left dorsolateral prefrontal cortex than healthy male controls. Our results are complementary to the findings of functional imaging and post-mortem studies that demonstrate abnormalities in the dorsolateral prefrontal cortex in bipolar patients.

Idioma originalEnglish (US)
Páginas (desde-hasta)541-544
Número de páginas4
EstadoPublished - abr 25 2005

ASJC Scopus subject areas

  • General Neuroscience


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