Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses

Brian Krumm, Yan Xiang, Junpeng Deng

Producción científica: Review articlerevisión exhaustiva

67 Citas (Scopus)

Resumen

Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.

Idioma originalEnglish (US)
Páginas (desde-hasta)526-538
Número de páginas13
PublicaciónProtein Science
Volumen23
N.º5
DOI
EstadoPublished - may 2014

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry

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