Stimulation of thermogenesis in men after combined glucose-long-chain triglyceride infusion

D. Thiebaud, K. Acheson, Y. Schutz, J. P. Felber, A. Golay, R. A. Defronzo, E. Jéquier

Producción científica: Articlerevisión exhaustiva

33 Citas (Scopus)


The effect of combined long-chain triglyceride infusion (Intralipid 20%) with graded doses of insulin/glucose on energy expenditure was examined in 17 healthy young male volunteers by using the euglycemic insulin clamp technique in combination with indirect calorimetry. Intralipid was infused for 90 min at a constant rate of 0.23 g/min; plasma free fatty acids increased from base-line values of 380 ± 8 μmol to steady state levels of 650 ± 12 μmol/l. After 90 min the Intralipid was continued and insulin was infused at three rates (0.5, 2, and 4 mU/kg. min) to achieve steady state hyperinsulinemic plateaus of 63 ± 4, 167 ± 10, and 410 ± 15 μU/ml. Plasma glucose concentration was maintained constant at basal euglycemic levels (insulin clamp technique) by infusing glucose at 0.24, 0.48, and 0.59 g/min. respectively. Glucose storage during the insulin clamp (ie, glucose uptake minus glucose oxidation) was 0.3, 0.33, and 0.40 g/min for each group and exogenous lipid storage was 0.17, 0.18, and 0.19 g/min, respectively. The net increment in energy expenditure was 0.15, 0.24, and 0.26 kcal/min, respectively, which represents 8.5% of the energy content of the total amount of glucose and lipid stored. The experimentally determined value (~9%) for the cost of storing both glucose and lipid was found to be significantly greater than predicted by stoichiometric calculations. However, the experimental value for the combined infusion was less than that observed for glucose storage alone (12%). This finding provides support for the use of combined glucose/fat infusion in parenteral nutritions as it is used more economically than when glucose is infused alone.

Idioma originalEnglish (US)
Páginas (desde-hasta)603-611
Número de páginas9
PublicaciónUnknown Journal
EstadoPublished - 1983
Publicado de forma externa

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Medicine (miscellaneous)


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