Stimulation effect of SO₂ derivatives modulated by MgSO ₄ on sodium channels in rat hippocampal neurons

Modulation of MgSO₄ for SO₂ derivative - induced stimulation on voltage - gated sodium channels in rat hippocampal neurons was investigated by using the whole-cell patch clamp techniques. The results indicated that MgSO₄ attenuated SO₂ derivative-induced augment on Na⁺ currents, and this action was positively related with the concentration of MgSO₄ but negatively related with the concentration of SO₂ derivatives. In addition, adding MgSO ₄ at different times would obviously inhibit the effect of SO ₂ derivatives on Na⁺ currents. It suggested that MgSO ₄ inhibited SO₂ derivative-induced stimulation on voltage-gated sodium channels in rat hippocampal neurons, which implicates the possible mechanisms for MgSO₄ protecting neuron against neuronal dysfunction resulting from SO₂ exposure.