Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats

Fabio Antônio Borges Vigil, Ieda de Fátima Oliveira-Silva, Lívia Freire Ferreira, Silvia Rejane Castanheira Pereira, Angela Maria Ribeiro

Producción científica: Articlerevisión exhaustiva

11 Citas (Scopus)

Resumen

The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TD deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function.

Idioma originalEnglish (US)
Páginas (desde-hasta)140-142
Número de páginas3
PublicaciónBehavioural Brain Research
Volumen210
N.º1
DOI
EstadoPublished - jun 2010
Publicado de forma externa

ASJC Scopus subject areas

  • Behavioral Neuroscience

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