SIRT6: therapeutic target for nonalcoholic fatty liver disease

Mengwei Zang; Bin Gao

doi:10.1016/j.tem.2022.10.004

SIRT6: therapeutic target for nonalcoholic fatty liver disease

Mengwei Zang
, Bin Gao

Producción científica: Short survey › revisión exhaustiva

6 Citas (Scopus)

Resumen

Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight into the role of cytoplasmic SIRT6 in fatty acid oxidation, acting as a therapeutic target for combating nonalcoholic fatty liver disease (NAFLD).

Idioma original	English (US)
Páginas (desde-hasta)	801-803
Número de páginas	3
Publicación	Trends in Endocrinology and Metabolism
Volumen	33
N.º	12
DOI	https://doi.org/10.1016/j.tem.2022.10.004
Estado	Published - dic 2022

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "SIRT6: therapeutic target for nonalcoholic fatty liver disease",

abstract = "Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight into the role of cytoplasmic SIRT6 in fatty acid oxidation, acting as a therapeutic target for combating nonalcoholic fatty liver disease (NAFLD).",

keywords = "SIRT6, deacetylation, fatty acid oxidation, lipid metabolism, long-chain acyl-CoA synthase 5, nonalcoholic fatty liver disease",

author = "Mengwei Zang and Bin Gao",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = dec,

doi = "10.1016/j.tem.2022.10.004",

language = "English (US)",

volume = "33",

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TY - JOUR

T1 - SIRT6

T2 - therapeutic target for nonalcoholic fatty liver disease

AU - Zang, Mengwei

AU - Gao, Bin

PY - 2022/12

Y1 - 2022/12

N2 - Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight into the role of cytoplasmic SIRT6 in fatty acid oxidation, acting as a therapeutic target for combating nonalcoholic fatty liver disease (NAFLD).

AB - Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight into the role of cytoplasmic SIRT6 in fatty acid oxidation, acting as a therapeutic target for combating nonalcoholic fatty liver disease (NAFLD).

KW - SIRT6

KW - deacetylation

KW - fatty acid oxidation

KW - lipid metabolism

KW - long-chain acyl-CoA synthase 5

KW - nonalcoholic fatty liver disease

UR - https://www.scopus.com/pages/publications/85141771750

UR - https://www.scopus.com/pages/publications/85141771750#tab=citedBy

U2 - 10.1016/j.tem.2022.10.004

DO - 10.1016/j.tem.2022.10.004

M3 - Short survey

C2 - 36328906

AN - SCOPUS:85141771750

SN - 1043-2760

VL - 33

SP - 801

EP - 803

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 12

ER -

SIRT6: therapeutic target for nonalcoholic fatty liver disease

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