@article{bfc561482bd34d2284ca5f80daa386f4,
title = "SIRT6: therapeutic target for nonalcoholic fatty liver disease",
abstract = "Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight into the role of cytoplasmic SIRT6 in fatty acid oxidation, acting as a therapeutic target for combating nonalcoholic fatty liver disease (NAFLD).",
keywords = "deacetylation, fatty acid oxidation, lipid metabolism, long-chain acyl-CoA synthase 5, nonalcoholic fatty liver disease, SIRT6",
author = "Mengwei Zang and Bin Gao",
note = "Funding Information: This work was supported, in part, by the National Institutes of Health Grants RO1 DK100603 , RO1 DK121527 , and R21 AA026922 (to M.Z.). M.Z. is also supported, in part, by the Distinguished Chair Endowment Fund in Research from the Ewing Halsell Foundation at the University of Texas Health San Antonio, USA. This work was supported, in part, by the intramural program of NIAAA , NIH (to B.G.). Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",
year = "2022",
month = dec,
doi = "10.1016/j.tem.2022.10.004",
language = "English (US)",
volume = "33",
pages = "801--803",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "12",
}