@article{4a0f9c6590a241d8a62759eabc9da0db,
title = "Significance of epicardial and intrathoracic adipose tissue volume among type 1 diabetes patients in the DCCT/EDIC: A pilot study",
abstract = "Introduction: Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM. Method: EAT/IAT volumes in 100 patients, underwent non-contrast cardiac computed tomography in the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were measured by a certified reader. Fat was defined as pixels' density of -30 to -190 Hounsfield Unit. The associations were assessed using-Pearson partial correlation and linear regression models adjusted for gender and age with inverse probability sample weighting. Results: The weighted mean age was 43 years (range 32-57) and 53% were male. Adjusted for gender, Pearson correlation analysis showed a significant correlation between age and EAT/IAT volumes (both p<0.001). After adjusting for gender and age, participants with greater BMI, higher waist to hip ratio (WTH), higher weighted HbA1c, elevated triglyceride level, and a history of albumin excretion rate of equal or greater than 300 mg/d (AER≥300) or end stage renal disease (ESRD) had significantly larger EAT/IAT volumes. Conclusion: T1DM patients with greater BMI, WTH ratio, weighted HbA1c level, triglyceride level and AER≥300/ESRD had significantly larger EAT/IAT volumes. Larger sample size studies are recommended to evaluate independency.",
author = "{DCCT/EDIC Research Group} and Sirous Darabian and Backlund, {Jye Yu C.} and Cleary, {Patricia A.} and Nasim Sheidaee and Ionut Bebu and Lachin, {John M.} and Budoff, {Matthew J.} and Nathan, {D. M.} and B. Zinman and O. Crofford and Saul Genuth and J. Brown-Friday and J. Crandall and H. Engel and S. Engel and H. Martinez and M. Phillips and M. Reid and H. Shamoon and J. Sheindlin and R. Gubitosi-Klug and L. Mayer and S. Pendegast and H. Zegarra and D. Miller and L. Singerman and S. Smith-Brewer and M. Novak and J. Quin and M. Palmert and E. Brown and J. McConnell and P. Pugsley and P. Crawford and W. Dahms and D. Brillon and Lackaye, {M. E.} and S. Kiss and R. Chan and A. Orlin and M. Rubin and V. Reppucci and T. Lee and M. Heinemann and S. Chang and B. Levy and L. Jovanovic and M. Richardson and B. Bosco and J. Lynch",
note = "Funding Information: The DCCT/EDIC has been supported by U01 Cooperative Agreement grants (1982–93, 2011–2017), and contracts (1982–2012) with the Division of Diabetes Endocrinology and Metabolic Diseases of the National Institute of Diabetes and Digestive and Kidney Disease (current grant numbers U01 DK094176 and U01 DK094157), and through support by the National Eye Institute, the National Institute of Neurologic Disorders and Stroke, the General Clinical Research Centers Program (1993–2007), and Clinical Translational Science Center Program (2006-present), Bethesda, Maryland, USA. Publisher Copyright: {\textcopyright} 2016 Darabian et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2016",
month = jul,
day = "1",
doi = "10.1371/journal.pone.0159958",
language = "English (US)",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",
}