TY - JOUR
T1 - Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease
AU - The Alzheimer's Disease Sequencing Project (ADSP)
AU - Alzheimer’S Disease Neuroimaging Initiative (Adni)
AU - The BIOCARD Study Team
AU - Peterson, Amalia
AU - Sathe, Aditi
AU - Zaras, Dimitrios
AU - Yang, Yisu
AU - Durant, Alaina
AU - Deters, Kacie D.
AU - Shashikumar, Niranjana
AU - Pechman, Kimberly R.
AU - Kim, Michael E.
AU - Gao, Chenyu
AU - Mohd Khairi, Nazirah
AU - Li, Zhiyuan
AU - Yao, Tianyuan
AU - Huo, Yuankai
AU - Dumitrescu, Logan
AU - Gifford, Katherine A.
AU - Wilson, Jo Ellen
AU - Cambronero, Francis E.
AU - Risacher, Shannon L.
AU - Beason-Held, Lori L.
AU - An, Yang
AU - Arfanakis, Konstantinos
AU - Erus, Guray
AU - Davatzikos, Christos
AU - Tosun, Duygu
AU - Toga, Arthur W.
AU - Thompson, Paul M.
AU - Mormino, Elizabeth C.
AU - Habes, Mohamad
AU - Wang, Di
AU - Zhang, Panpan
AU - Schilling, Kurt
AU - Albert, Marilyn
AU - Kukull, Walter
AU - Biber, Sarah A.
AU - Landman, Bennett A.
AU - Johnson, Sterling C.
AU - Schneider, Julie
AU - Barnes, Lisa L.
AU - Bennett, David A.
AU - Jefferson, Angela L.
AU - Resnick, Susan M.
AU - Saykin, Andrew J.
AU - Hohman, Timothy J.
AU - Archer, Derek B.
N1 - Publisher Copyright:
© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2025/1
Y1 - 2025/1
N2 - INTRODUCTION: The effects of sex and apolipoprotein E (APOE)—Alzheimer's disease (AD) risk factors—on white matter microstructure are not well characterized. METHODS: Diffusion magnetic resonance imaging data from nine well-established longitudinal cohorts of aging were free water (FW)–corrected and harmonized. This dataset included 4741 participants (age = 73.06 ± 9.75) with 9671 imaging sessions over time. FW and FW-corrected fractional anisotropy (FAFWcorr) were used to assess differences in white matter microstructure by sex and APOE ε4 carrier status. RESULTS: Sex differences in FAFWcorr in projection tracts and APOE ε4 differences in FW limbic and occipital transcallosal tracts were most pronounced. DISCUSSION: There are prominent differences in white matter microstructure by sex and APOE ε4 carrier status. This work adds to our understanding of disparities in AD. Additional work to understand the etiology of these differences is warranted. Highlights: Sex and apolipoprotein E (APOE) ε4 carrier status relate to white matter microstructural integrity. Females generally have lower free water–corrected fractional anisotropy compared to males. APOE ε4 carriers tended to have higher free water than non-carriers.
AB - INTRODUCTION: The effects of sex and apolipoprotein E (APOE)—Alzheimer's disease (AD) risk factors—on white matter microstructure are not well characterized. METHODS: Diffusion magnetic resonance imaging data from nine well-established longitudinal cohorts of aging were free water (FW)–corrected and harmonized. This dataset included 4741 participants (age = 73.06 ± 9.75) with 9671 imaging sessions over time. FW and FW-corrected fractional anisotropy (FAFWcorr) were used to assess differences in white matter microstructure by sex and APOE ε4 carrier status. RESULTS: Sex differences in FAFWcorr in projection tracts and APOE ε4 differences in FW limbic and occipital transcallosal tracts were most pronounced. DISCUSSION: There are prominent differences in white matter microstructure by sex and APOE ε4 carrier status. This work adds to our understanding of disparities in AD. Additional work to understand the etiology of these differences is warranted. Highlights: Sex and apolipoprotein E (APOE) ε4 carrier status relate to white matter microstructural integrity. Females generally have lower free water–corrected fractional anisotropy compared to males. APOE ε4 carriers tended to have higher free water than non-carriers.
KW - Alzheimer's disease
KW - aging
KW - sex differences
KW - white matter disease
UR - https://www.scopus.com/pages/publications/85212794702
UR - https://www.scopus.com/pages/publications/85212794702#tab=citedBy
U2 - 10.1002/alz.14343
DO - 10.1002/alz.14343
M3 - Article
C2 - 39711105
AN - SCOPUS:85212794702
SN - 1552-5260
VL - 21
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 1
M1 - e14343
ER -