@article{930c3cfb2c0d4f4abb02d054520f5b19,
title = "Sex- And age-dependent genetics of longevity in a heterogeneous mouse population",
abstract = "DNA variants that modulate life span provide insight into determinants of health, disease, and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program (ITP), we detected a sex-independent quantitative trait locus (QTL) on chromosome 12 and identified sex-specific QTLs, some of which we detected only in older mice. Similar relations between life history and longevity were uncovered in mice and humans, underscoring the importance of early access to nutrients and early growth. We identified common age- and sex-specific genetic effects on gene expression that we integrated with model organism and human data to create a hypothesis-building interactive resource of prioritized longevity and body weight genes. Finally, we validated Hipk1, Ddost, Hspg2, Fgd6, and Pdk1 as conserved longevity genes using Caenorhabditis elegans life-span experiments.",
author = "Sleiman, {Maroun Bou} and Suheeta Roy and Gao, {Arwen W.} and Sadler, {Marie C.} and {von Alvensleben}, {Giacomo V.G.} and Hao Li and Saunak Sen and Harrison, {David E.} and Nelson, {James F.} and Randy Strong and Miller, {Richard A.} and Zolt{\'a}n Kutalik and Williams, {Robert W.} and Johan Auwerx",
note = "Funding Information: We thank all technical and scientific members of the Interventions Testing Program, who have produced and made the data available. We also thank J.-D. Morel, G. Benegiamo, and L. Goeminne for comments on the manuscript. Ecole Polytechnique F{\'e}d{\'e}rale de Lausanne (J.A.); European Research Council grant ERC-AdG-787702 (J.A.); Swiss National Science Foundation grant 31003A-179435 (J.A.); Swiss National Science Foundation grant 310030-189147 (Z.K.); National Institutes of Health grant AG043930 (R.W., J.A.); National Institutes of Health grant AG022303 (R.M.); National Institutes of Health grant AG022308 (D.H.); National Institutes of Health grant AG022307 (R.S.); Glenn Foundation for Medical Research (R.M.); R.S. is supported by a Senior Research Career Scientist Award from the Department of Veterans Affairs Office of Research and Development. Publisher Copyright: {\textcopyright} 2022 American Association for the Advancement of Science. All rights reserved.",
year = "2022",
month = sep,
day = "30",
doi = "10.1126/science.abo3191",
language = "English (US)",
volume = "377",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6614",
}