Serological analysis of the repertoire of human cancer antigens and autoantigens

E. P. Koroleva, M. A. Lagar'kova, S. V. Khlgatian, Yu V. Shebzukhov, A. A. Meshcheryakov, M. R. Lichinitser, S. A. Nedospasov, D. V. Kuprash

Producción científica: Articlerevisión exhaustiva

1 Cita (Scopus)

Resumen

The spectrum of human antigens allows a monitoring of various pathological processes such as autoimmune disorders and tumorigenesis. Serological analysis of cDNA expression libraries (SEREX) is now used to search for new cancer-associated antigens, which are potential diagnostic markers or targets for immunotherapy of cancer. The results obtained for several solid tumors are reviewed. Groups of antigens detectable by SEREX, causes of immunogenicity of autoantigens, and prospective implication of antigens in diagnostics and monitoring of cancer are discussed.

Idioma originalEnglish (US)
Páginas (desde-hasta)233-238
Número de páginas6
PublicaciónMolekulyarnaya Biologiya
Volumen38
N.º2
EstadoPublished - 2004
Publicado de forma externa

ASJC Scopus subject areas

  • General Medicine

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