@article{596c1e13baf242ffaab542a6138ba8aa,
title = "Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β",
abstract = "Borges da Silva et al. report that the extracellular ATP receptor P2RX7 promotes generation of virus-specific tissue-resident memory (Trm) CD8+ T cells through induction of the TGF-β signaling pathway. Furthermore, long-term maintenance of Trm cells relies on continuous P2RX7 signaling.",
keywords = "P2RX7, TGF-β, eATP, memory CD8 T cells, non-lymphoid tissue",
author = "{Borges da Silva}, Henrique and Changwei Peng and Haiguang Wang and Wanhainen, {Kelsey M.} and Chaoyu Ma and Sharon Lopez and Alexander Khoruts and Nu Zhang and Jameson, {Stephen C.}",
note = "Funding Information: We thank Wanjun Chen (NIDCR) for providing the MiT-Tgfbr2 overexpression vector. We also thank the members of the Jamequist lab for critically reviewing the manuscript. S.C.J. was funded by NIAID ( R01 AI038903 and AI145147 ). H.B.d.S. was funded by NIAID ( K99/R00 AI139381 ) and a Paul C. Shiverick/CRI Irvington fellowship. Funding Information: We thank Wanjun Chen (NIDCR) for providing the MiT-Tgfbr2 overexpression vector. We also thank the members of the Jamequist lab for critically reviewing the manuscript. S.C.J. was funded by NIAID (R01 AI038903 and AI145147). H.B.d.S. was funded by NIAID (K99/R00 AI139381) and a Paul C. Shiverick/CRI Irvington fellowship. H.B.d.S. and S.C.J. conceived the project. H.B.d.S. and S.C.J. conceived the experiments. A.K. N.Z. and S.C.J. provided mice and reagents for all experiments. H.B.d.S. C.P. H.W. K.M.W. C.M. and S.L. performed the experiments and analyzed the data. H.B.d.S. and S.C.J. wrote the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = jul,
day = "14",
doi = "10.1016/j.immuni.2020.06.010",
language = "English (US)",
volume = "53",
pages = "158--171.e6",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "1",
}