TY - JOUR
T1 - Self-reported physical activity and relations to growth and neurotrophic factors in diabetes mellitus
T2 - The framingham offspring study
AU - Spartano, Nicole L.
AU - Davis-Plourde, Kendra L.
AU - Himali, Jayandra J.
AU - Murabito, Joanne M.
AU - Vasan, Ramachandran S.
AU - Beiser, Alexa S.
AU - Seshadri, Sudha
N1 - Publisher Copyright:
Copyright © 2019 Nicole L. Spartano et al.
PY - 2019
Y1 - 2019
N2 - Aims. Circulating insulin-like growth factor- (IGF-) 1, vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) levels are often lower in individuals with diabetes mellitus (DM) and are important for repairing vascular and neuronal dysfunction. The purpose of this investigation was to determine the cross-sectional relations of physical activity to circulating concentrations of IGF-1, VEGF, and BDNF in individuals with and without DM. Methods. In 1730 participants from the Framingham Offspring Study examination cycle 7, including those with DM (n = 179, mean age 64 years, 39% women) and without DM (n = 1551, mean age 60 years, 46% women), we related self-reported physical activity variables to circulating concentrations of IGF-1, VEGF, and BDNF using linear multivariable regression models. We also tested for interactions by age. Participants with prevalent cardiovascular disease, stroke, and dementia or taking hormone replacement therapy were excluded. Results. In participants with DM, more ambulatory physical activity was associated with higher IGF-1 levels (β ± standard error SE = 0 22 ± 0 08, p = 0 009), and more total physical activity was related to higher BDNF levels (β ± SE = 0 18 ± 0 08, p = 0 035), but physical activity was not significantly related to circulating VEGF. In participants without DM, no associations were observed. Moreover, in the examination of interactions by age, the association of ambulatory physical activity with IGF-1 levels was only observed in older adults with DM (age ≥ 60 years, β ± SE = 0 23 ± 0 11, p = 0 042) but not in middle-aged adults with DM (age < 60 years, β ± SE = 0 06 ± 0 13, p = 0 645). Conclusion. Our results suggest that more physical activity is associated with higher circulating IGF-1 and BDNF in participants with DM. These results, dissecting interactions by both age and DM status, may also help to explain some of the inconsistent results in studies relating physical activity to growth and neurotrophic factors.
AB - Aims. Circulating insulin-like growth factor- (IGF-) 1, vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) levels are often lower in individuals with diabetes mellitus (DM) and are important for repairing vascular and neuronal dysfunction. The purpose of this investigation was to determine the cross-sectional relations of physical activity to circulating concentrations of IGF-1, VEGF, and BDNF in individuals with and without DM. Methods. In 1730 participants from the Framingham Offspring Study examination cycle 7, including those with DM (n = 179, mean age 64 years, 39% women) and without DM (n = 1551, mean age 60 years, 46% women), we related self-reported physical activity variables to circulating concentrations of IGF-1, VEGF, and BDNF using linear multivariable regression models. We also tested for interactions by age. Participants with prevalent cardiovascular disease, stroke, and dementia or taking hormone replacement therapy were excluded. Results. In participants with DM, more ambulatory physical activity was associated with higher IGF-1 levels (β ± standard error SE = 0 22 ± 0 08, p = 0 009), and more total physical activity was related to higher BDNF levels (β ± SE = 0 18 ± 0 08, p = 0 035), but physical activity was not significantly related to circulating VEGF. In participants without DM, no associations were observed. Moreover, in the examination of interactions by age, the association of ambulatory physical activity with IGF-1 levels was only observed in older adults with DM (age ≥ 60 years, β ± SE = 0 23 ± 0 11, p = 0 042) but not in middle-aged adults with DM (age < 60 years, β ± SE = 0 06 ± 0 13, p = 0 645). Conclusion. Our results suggest that more physical activity is associated with higher circulating IGF-1 and BDNF in participants with DM. These results, dissecting interactions by both age and DM status, may also help to explain some of the inconsistent results in studies relating physical activity to growth and neurotrophic factors.
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U2 - 10.1155/2019/2718465
DO - 10.1155/2019/2718465
M3 - Article
C2 - 30729134
AN - SCOPUS:85061157638
SN - 2314-6745
VL - 2019
JO - Journal of diabetes research
JF - Journal of diabetes research
M1 - 2718465
ER -