Selective keratinocyte stimulation is sufficient to evoke nociception in mice

Zixuan Pang, Takashi Sakamoto, Vinod Tiwari, Yu Shin Kim, Fei Yang, Xinzhong Dong, Ali D. Güler, Yun Guan, Michael J. Caterina

Producción científica: Articlerevisión exhaustiva

96 Citas (Scopus)


The skin epidermis is densely innervated by peripheral sensory nerve endings. Nociceptive neurons, whose terminals are in close contact with epidermal keratinocytes, can be activated directly by noxious physical and chemical stimuli to trigger pain. However, whether keratinocytes can signal acutely to sensory nerve terminals to initiate pain in vivo remains unclear. Here, using the keratin 5 promoter to selectively express the capsaicin receptor TRPV1 in keratinocytes of TRPV1-knockout mice, we achieved specific stimulation of keratinocytes with capsaicin. Using this approach, we found that keratinocyte stimulation was sufficient to induce strong expression of the neuronal activation marker, c-fos, in laminae I and II of the ipsilateral spinal cord dorsal horn and to evoke acute paw-licking nocifensive behavior and conditioned place aversion. These data provide direct evidence that keratinocyte stimulation is sufficient to evoke acute nociception-related responses.

Idioma originalEnglish (US)
Páginas (desde-hasta)656-665
Número de páginas10
EstadoPublished - abr 1 2015
Publicado de forma externa

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Anesthesiology and Pain Medicine


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