Seed in soil, with an epigenetic view

Huey Jen L. Lin, Tao Zuo, Jennifer R. Chao, Zhengang Peng, Lisa K. Asamoto, Sonya S. Yamashita, Tim H.M. Huang

Producción científica: Review articlerevisión exhaustiva

26 Citas (Scopus)


It is becoming increasingly evident that discrete genetic alterations in neoplastic cells alone cannot explain multistep carcinogenesis whereby tumor cells are able to express diverse phenotypes during the complex phases of tumor development and progression. The epigenetic model posits that the host microenvironment exerts an initial, inhibitory constraint on tumor growth that is followed by acceleration of tumor progression through complex cell-matrix interactions. This review emphasizes the epigenetic aspects of breast cancer development in light of such interactions between epithelial cells ("seed") and the tumor microenvironment ("soil"). Our recent research findings suggest that epigenetic perturbations induced by the tumor microenvironment may play a causal role in promoting breast cancer development. It is believed that abrogation of these initiators could offer a promising therapeutic strategy.

Idioma originalEnglish (US)
Páginas (desde-hasta)920-924
Número de páginas5
PublicaciónBiochimica et Biophysica Acta - General Subjects
EstadoPublished - sept 2009
Publicado de forma externa

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry


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