@article{71cbdd1db7434f1e8c4eb7e0e2a00a2f,
title = "Routine CSF Analysis in Coccidioidomycosis Is Not Required",
abstract = "Although routinely done, there has been no evaluation of the utility of performing routine cerebrospinal fluid (CSF) examination in patients with active coccidioidomycosis and high complement fixation (IgG) antibody titers or other risk factors for disseminated infection. In our review 100\% of patients diagnosed with coccidioidal meningitis had at least one sign or symptom consistent with infection of the central nervous system, headache was present in 100\% of those with meningitis, while no patients without signs/symptoms of CNS infection were found to have coccidioidal meningitis, irrespective of antibody titers or other risk factors. Thus routine lumbar puncture may be unnecessary for patients with coccidioidomycosis who lack suggestive clinical symptoms.",
author = "George Thompson and Sharon Wang and Robert Bercovitch and Michael Bolaris and \{Van Den Akker\}, Dane and Sandra Taylor and Rodrigo Lopez and Antonio Catanzaro and Jose Cadena and Peter Chin-Hong and Brad Spellberg",
note = "Funding Information: Funding for this study was generously provided by Pfizer. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. Funding Information: We wish to thank Stuart Cohen MD for helpful comments during the writing of this manuscript and we thank the research staff at each of the sites for invaluable assistance. “The project described was supported by the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), through grant \#UL1 TR000002.” ",
year = "2013",
month = may,
day = "22",
doi = "10.1371/journal.pone.0064249",
language = "English (US)",
volume = "8",
journal = "PloS one",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",
}