Roles of Melatonin in Maintaining Mitochondrial Welfare Focus on Renal Cells

Feres José Mocayar Marón, Emiliano Diez, Russel J. Reiter, Walter Manucha

Producción científica: Chapter

1 Cita (Scopus)


Current knowledge highlights aspects never before suspected of melatonin, a known chrono-regulatory hormone initially described in the pineal gland is present in most tissues and fulfills fundamental protective functions in vital organelles such as mitochondria. In this sense, recent findings show that alterations of mitochondrial function are closely related to loss of melatonin regulation. This chapter describes the most innovative aspects of melatonin for mitochondrial welfare, with particular emphasis on the renal cells. Alterations in the mitochondrial signaling pathways associated with the loss of melatonin-mediated regulation induce in renal cells a functional decoupling with the development of renal and finally cardiovascular tissue pathology. Although it is an endogenous compound, melatonin would be a useful exogenous pharmacological tool for many diseases however, additional clinical trials are needed to demonstrate its translational power.

Idioma originalEnglish (US)
Título de la publicación alojadaHandbook of Mitochondrial Dysfunction
EditorialTaylor and Francis
Número de páginas10
ISBN (versión digital)9780429811777
ISBN (versión impresa)9780429443336
EstadoPublished - ene 1 2019

ASJC Scopus subject areas

  • General Medicine
  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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