Roles of DNA helicases in the mediation and regulation of homologous recombination

James M. Daley, Hengyao Niu, Patrick Sung

Producción científica: Chapter

17 Citas (Scopus)

Resumen

Homologous recombination (HR) is an evolutionarily conserved process that eliminates DNA double-strand breaks from chromosomes, repairs injured DNA replication forks, and helps orchestrate meiotic chromosome segregation. Recent studies have shown that DNA helicases play multifaceted roles in HR mediation and regulation. In particular, the S. cerevisiae Sgs1 helicase and its human ortholog BLM helicase are involved in not only the resection of the primary lesion to generate single-stranded DNA to prompt the assembly of the HR machinery, but they also function in somatic cells to suppress the formation of chromosome arm crossovers during HR. On the other hand, the S. cerevisiae Mph1 and Srs2 helicases, and their respective functional equivalents in other eukaryotes, suppress spurious HR events and favor the formation of noncrossovers via distinct mechanisms. Thus, the functional integrity of the HR process and HR outcomes are dependent upon these helicase enzymes. Since mutations in some of these helicases lead to cancer predisposition in humans and mice, studies on them have clear relevance to human health and disease.

Idioma originalEnglish (US)
Título de la publicación alojadaDNA Helicases and DNA Motor Proteins
EditorialSpringer New York LLC
Páginas185-202
Número de páginas18
ISBN (versión impresa)9781461450368
DOI
EstadoPublished - 2013
Publicado de forma externa

Serie de la publicación

NombreAdvances in Experimental Medicine and Biology
Volumen767
ISSN (versión impresa)0065-2598

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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