Role of stent design and coatings on restenosis and thrombosis

Hidehiko Hara, Masato Nakamura, Julio C. Palmaz, Robert S. Schwartz

Producción científica: Review articlerevisión exhaustiva

158 Citas (Scopus)

Resumen

More than 15 years have passed since stent technology was introduced by Sigwart et al. [U. Sigwart, J. Puel, V. Mirkovitch, F. Joffe, et al. Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty. N. Engl. J. Med. 316 (1987) 701-706.] among interventional cardiologists. Recently drug eluting stents have assumed dominance in the interventional world as positive trial results revealed their efficacy for preventing restenosis. Stent design, delivery-vehicle materials, and drug properties affect the function of these stents. Stainless steel stents with tubular and multicellular design have proven superior to coil or hybrid stent models. This chapter describes stents which have subtle influences of modular design, metal coverage, strut thickness, strut shape, surface smoothness, and coating materials like an alloy composition.

Idioma originalEnglish (US)
Páginas (desde-hasta)377-386
Número de páginas10
PublicaciónAdvanced Drug Delivery Reviews
Volumen58
N.º3
DOI
EstadoPublished - jun 3 2006

ASJC Scopus subject areas

  • Pharmaceutical Science

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