Role of GABAA receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase

Haviryaji S.G. Kalluri, Maharaj K. Ticku

Resultado de la investigación: Articlerevisión exhaustiva

32 Citas (Scopus)

Resumen

In the present study, we demonstrate the involvement of GABAA receptors in the ethanol-mediated modulation of extracellular signal-regulated kinases (ERK). Intraperitoneal (i.p.) administration of ethanol (3.5 g), flurazepam (75 mg) or (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cycloheptane-5,10-iminemaleate (MK-801) (0.4 mg/kg body weight) decreased, while picrotoxin (10 mg/kg body weight) increased, the phosphorylation of ERK following 10 min of their injection. However, the picrotoxin-induced phosphorylation of ERK was inhibited by ethanol, but was not affected by MK-801. These results indicate that ethanol's inhibitory effect on ERK phosphorylation may involve the modulation of GABAA receptor function.

Idioma originalEnglish (US)
Páginas (desde-hasta)51-54
Número de páginas4
PublicaciónEuropean Journal of Pharmacology
Volumen451
N.º1
DOI
EstadoPublished - sept. 6 2002

ASJC Scopus subject areas

  • Pharmacology

Huella

Profundice en los temas de investigación de 'Role of GABAA receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase'. En conjunto forman una huella única.

Citar esto