Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers

Hiroto Hatakeyama; Sherry Y. Wu; Yasmin A. Lyons; Sunila Pradeep; Wanqin Wang; Qian Huang; Karem A. Court; Tao Liu; Song Nie; Cristian Rodriguez-Aguayo; Fangrong Shen; Yan Huang; Takeshi Hisamatsu; Takashi Mitamura; Nicholas Jennings; Jeajun Shim; Piotr L. Dorniak; Lingegowda S. Mangala; Marco Petrillo; Vladislav A. Petyuk; Athena A. Schepmoes; Anil K. Shukla; Madeline Torres-Lugo; Ju Seog Lee; Karin D. Rodland; Anna Fagotti; Gabriel Lopez-Berestein; Chun Li; Anil K. Sood

doi:10.1016/j.celrep.2016.10.020

Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers

Hiroto Hatakeyama, Sherry Y. Wu, Yasmin A. Lyons, Sunila Pradeep, Wanqin Wang, Qian Huang, Karem A. Court, Tao Liu, Song Nie, Cristian Rodriguez-Aguayo, Fangrong Shen, Yan Huang, Takeshi Hisamatsu, Takashi Mitamura, Nicholas Jennings, Jeajun Shim, Piotr L. Dorniak, Lingegowda S. Mangala, Marco Petrillo, Vladislav A. PetyukAthena A. Schepmoes, Anil K. Shukla, Madeline Torres-Lugo, Ju Seog Lee, Karin D. Rodland, Anna Fagotti, Gabriel Lopez-Berestein, Chun Li, Anil K. Sood

Producción científica: Article › revisión exhaustiva

22 Citas (Scopus)

Resumen

Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.

Idioma original	English (US)
Páginas (desde-hasta)	1621-1631
Número de páginas	11
Publicación	Cell Reports
Volumen	17
N.º	6
DOI	https://doi.org/10.1016/j.celrep.2016.10.020
Estado	Published - nov 1 2016
Publicado de forma externa	Sí

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2016.10.020

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Hatakeyama, H., Wu, S. Y., Lyons, Y. A., Pradeep, S., Wang, W., Huang, Q., Court, K. A., Liu, T., Nie, S., Rodriguez-Aguayo, C., Shen, F., Huang, Y., Hisamatsu, T., Mitamura, T., Jennings, N., Shim, J., Dorniak, P. L., Mangala, L. S., Petrillo, M., ... Sood, A. K. (2016). Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers. Cell Reports, 17(6), 1621-1631. https://doi.org/10.1016/j.celrep.2016.10.020

Hatakeyama, H, Wu, SY, Lyons, YA, Pradeep, S, Wang, W, Huang, Q, Court, KA, Liu, T, Nie, S, Rodriguez-Aguayo, C, Shen, F, Huang, Y, Hisamatsu, T, Mitamura, T, Jennings, N, Shim, J, Dorniak, PL, Mangala, LS, Petrillo, M, Petyuk, VA, Schepmoes, AA, Shukla, AK, Torres-Lugo, M, Lee, JS, Rodland, KD, Fagotti, A, Lopez-Berestein, G, Li, C & Sood, AK 2016, 'Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers', Cell Reports, vol. 17, n.º 6, pp. 1621-1631. https://doi.org/10.1016/j.celrep.2016.10.020

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abstract = "Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.",

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AU - Wang, Wanqin

AU - Huang, Qian

AU - Court, Karem A.

AU - Liu, Tao

AU - Nie, Song

AU - Rodriguez-Aguayo, Cristian

AU - Shen, Fangrong

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AU - Hisamatsu, Takeshi

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AU - Mangala, Lingegowda S.

AU - Petrillo, Marco

AU - Petyuk, Vladislav A.

AU - Schepmoes, Athena A.

AU - Shukla, Anil K.

AU - Torres-Lugo, Madeline

AU - Lee, Ju Seog

AU - Rodland, Karin D.

AU - Fagotti, Anna

AU - Lopez-Berestein, Gabriel

AU - Li, Chun

AU - Sood, Anil K.

PY - 2016/11/1

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N2 - Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.

AB - Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.

KW - CTGF

KW - DOPC-liposome

KW - copper sulfide nanoparticle

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Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers

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ASJC Scopus subject areas

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