Retinotopic organization of human visual cortex mapped with positron-emission tomography

Peter T. Fox, Francis M. Miezin, John M. Allman, David C. Van Essen, Marcus E. Raichlei

Producción científica: Articlerevisión exhaustiva

226 Citas (Scopus)


The retinotopic organization of primary visual cortex was mapped in normal human volunteers. Positron-emission tomographic measurements of regional cerebral blood flow were employed to detect focal functional brain activation. Oxygen-15-labeled water, delivered by intravenous bolus, was used as the blood flow tracer to allow multiple stimulated-state (n = 5) and control-state (n = 3) measurements to be acquired for each of 7 subjects. Responses were identified by applying a maximum-detection algorithm to subtraction-format images of the stimulus-induced change in cerebral blood flow. Response locales were described using a standardized system of stereotactic coordinates. Changes in stimulus location (macular, perimacular, peripheral, upper-field, lower-field) caused systematic, highly significant changes in response locale witin visual cortex. Discrete extrastriate visual responses were also observed.

Idioma originalEnglish (US)
Páginas (desde-hasta)913-922
Número de páginas10
PublicaciónJournal of Neuroscience
EstadoPublished - 1987
Publicado de forma externa

ASJC Scopus subject areas

  • General Neuroscience


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