Restoration of ovulatory cycles by young ovarian grafts in aging mice: Potentiation by long-term ovariectomy decreases with age

L. S. Felicio, J. F. Nelson, R. G. Gosden, C. E. Finch

Producción científica: Articlerevisión exhaustiva

88 Citas (Scopus)

Resumen

The relative contributions of ovarian and hypothalamic-pituitary factors to the anovulatory status of aging mice were evaluated by measuring the capacity of mice to resume ovulatory cyclicity after receiving young ovaries under the renal capsule. Young grafts partially restored cyclicity if old hosts were acutely ovariectomized but almost fully restored cyclic ovulatory function if the old hosts had been ovariectomized early in adulthood. With advancing age, however, the efficacy of the grafts declined progressively in both acute and long-term ovariectomized groups. These data show that both ovarian and hypothalamic-pituitary aging contribute to the etiology and anovulation. Although chronic withdrawal from ovarian secretions retards the age of onset of hypothalamic-pituitary aging, the duration of this ameliorative effect is limited by progressive ovary-independent neuroendocrine dysfunction.

Idioma originalEnglish (US)
Páginas (desde-hasta)6076-6080
Número de páginas5
PublicaciónProceedings of the National Academy of Sciences of the United States of America
Volumen80
N.º19 I
DOI
EstadoPublished - 1983
Publicado de forma externa

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