Resolution of cryptogenic new onset refractory status epilepticus with tocilizumab

Jonathan P. Donnelly, Nidhi Kasatwar, Shaheryar Hafeez, Ali Seifi, Andrea Gilbert, Colleen Barthol, Clay Small, C. Ákos Szabó

Resultado de la investigación: Articlerevisión exhaustiva

8 Citas (Scopus)


New onset refractory status epilepticus (NORSE) was defined by the International League Against Epilepsy as occurring in patients presenting without a prior diagnosis of epilepsy or other neurological disease, with seizures that persist beyond 24 h. There is still a need to develop new treatment strategies for NORSE, particularly for those patients who are least responsive to conventional medical therapies. We present a case of a young female patient without any medical history presenting with status epilepticus, which was refractory not only to anti-seizure medications and anesthetics, but also to conventional immunomodulatory therapies. After nine weeks of electroclinical seizure activity, the patient responded to two doses of tocilizumab.

Idioma originalEnglish (US)
Número de artículo100431
PublicaciónEpilepsy and Behavior Reports
EstadoPublished - ene 2021

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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