TY - JOUR
T1 - Repurposing auranofin as an antifungal
T2 - In vitro activity against a variety of medically important fungi
AU - Wiederhold, Nathan P.
AU - Patterson, Thomas F.
AU - Srinivasan, Anand
AU - Chaturvedi, Ashok K.
AU - Fothergill, Annette W.
AU - Wormley, Floyd L.
AU - Ramasubramanian, Anand K.
AU - Lopez-Ribot, José L.
N1 - Publisher Copyright:
© 2017 Taylor & Francis.
PY - 2017/2/17
Y1 - 2017/2/17
N2 - Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.
AB - Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.
KW - antifungal susceptibility
KW - auranofin
KW - repurposing
KW - spectrum of action
UR - https://www.scopus.com/pages/publications/84976291300
UR - https://www.scopus.com/pages/publications/84976291300#tab=citedBy
U2 - 10.1080/21505594.2016.1196301
DO - 10.1080/21505594.2016.1196301
M3 - Article
C2 - 27268469
AN - SCOPUS:84976291300
SN - 2150-5594
VL - 8
SP - 138
EP - 142
JO - Virulence
JF - Virulence
IS - 2
ER -